Paroxetine

It should be noted that this was the first antidepressant I ever took. My initial reaction was therefore hypersensitive.

The overwhelming effect of paroxetine manifested as hypomania, for which I chose to lower the dose first to 10 mg daily, and later to 10 mg 5 times a week, which comes down to 7,1 mg/d.

After four months, tolerance set in. After that, no further therapeutic effects of paroxetine where ever noticable on monotherapy, even at doses to 60 mg. Nevertheless I do still use it, be it in combination with clomipramine. The effect consists of adressing the liver-enzyme CYP2D6, causing rise of the clomipramine-bloodrate while cancelling the tremor which is typical of clomipramine at bloodrates beyond approximately 590 μg/l.

Overreacting to subtherapeutic doses of an SSRI is consistently reported by people suffering Asperger-syndrome, like me.